Dan Castellaneta .... Homer Simpson/Grampa/Barney Gumble/Krusty the Klown/Groundskeeper Willie/Mayor Quimby/Hans Moleman/Sideshow Mel/Others (voice)
Julie Kavner .... Marge Simpson/Patty & Selma Bouvier/Others (voice)
Nancy Cartwright .... Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney/Others (voice)
Yeardley Smith .... Lisa Simpson (voice)
Hank Azaria .... Moe Szyslak/Chief Wiggum/Apu/Comic Book Guy/Cletus/Prof. Frink/Others (voice)
Harry Shearer .... Montgomery Burns/Waylon Smithers/Ned Flanders/Kent Brockman/Rev. Lovejoy/Principal Skinner/Dr. Hibbert/Rainer Wolfcastle/Others (voice)
Marcia Wallace .... Edna Krabappel (1990-) (voice)
Phil Hartman .... Lionel Hutz/Troy McClure (1991-1998) (voice)
Tress MacNeille .... Jimbo Jones/Agnes Skinner/Others (voice)
Pamela Hayden .... Milhouse Van Houten/Rod Flanders/Others (voice)
Maggie Roswell .... Maude Flanders/Helen Lovejoy/Others (1990-1999, 2002-) (voice)
Russi Taylor .... Martin Prince/Others (1990-) (voice)
Doris Grau .... Lunchlady Doris (1989-1996) (voice)
Karl Wiedergott .... Additional Voices (1998-) (voice)
Marcia Mitzman Gaven .... Maude Flanders/Helen Lovejoy/Others (1999-2002) (voice)

The FOX network's most successful series to date was a spin-off from The Tracey Ullman Show. Originally appearing on that series as a 1 minute filler, the executive producers of that series, James L. Brooks & Sam Simon decided that these characters could support a half hour series. So they did it and started the longest running animated series in primetime network television.

Part of this family's broad appeal has allowed them to make endorsements, such as the numerous commercials they've appeared in for Butterfinger candy bars.