Without a Trace is a fast-paced procedural drama about the Missing Persons Squad of the Federal Bureau of Investigation. The sole responsibility of the special task force is to find missing persons by applying advanced psychological profiling techniques to peel back the layers of the victims' lives and trace their whereabouts in an effort to discover whether they have been abducted, been murdered, committed suicide or simply run away. The team reconstructs a "Day of Disappearance" timeline that details every minute of the 24 hours prior to the disappearance, following one simple rule: learn who the victim is in order to learn where the victim is.

Senior agent Jack Malone (Anthony LaPaglia) heads the dedicated team that knows too well that every second counts when someone vanishes. His squad includes Samantha Spade (Poppy Montgomery), an agent who doesn't let her good looks get in the way of being tough; Vivian Johnson (Marianne Jean-Baptiste), a no-nonsense investigator; Danny Taylor (Enrique Murciano), an intense and private agent; and Martin Fitzgerald (Eric Close), the newest member of the team, considered a lightweight by the squad because his only experience involves fighting white-collar crime.

Without a Trace has aired Thursday nights on CBS since it premiered in September of 2002.