This single-camera comedy introduces us to Samantha "Sam" Newly (played by Christina Applegate), a psychiatrist and hit-and-run victim who awakens after being in a coma for eight days, only to find she has amnesia. With no memories of the past, she must rediscover everything about her life and herself by looking for clues from her past. Sam discovers that she wasn't a very nice person to most people and she is determined to change that. She also discovers that she cheated on her boyfriend Todd (played by Barry Watson) with a married man. Sam attempts to live with Todd after the accident, but soon realizes it won't work and has no other choice but to move back home with her parents. Sam even learns that her "accident" was no accident at all, but a failed attempt at someone trying to kill her, but who? Slowly but surely little parts of her start to emerge to the delight of some and to the shock of others. Will she change or will she act like she did before her amnesia?