Summary:

Johnny Galecki ... Leonard Hofstadter (18 episodes, 2007-2008)
Jim Parsons ... Sheldon Cooper (18 episodes, 2007-2008)
Kaley Cuoco ... Penny (18 episodes, 2007-2008)
Simon Helberg ... Howard Wolowitz (18 episodes, 2007-2008)
Kunal Nayyar ... Rajnesh Koothrappali / ... (18 episodes, 2007-2008)

Created by writer/producers Chuck Lorre (of Two And A Half Men) and Bill Prady (of Gilmore Girls) comes The Big Bang Theory, a sitcom that shows what happens when hyperintelligent roommates/physicists Sheldon and Leonard meet Penny, a beautiful woman moving in next door--and realize they know next to nothing about life outside of the lab. Rounding out the crew are the smarmy Wolowitz, who thinks he's as sexy as he is brainy, and Koothrappali, who suffers from an inability to speak in the presence of a woman.
The show distinguishes itself by being unafraid to toss scientific references and technobabble into an otherwise standard sitcom, even employing a physicist to keep things accurate. In doing so, it allows Sheldon and Leonard to do for science what Frasier's Crane brothers did for fine dining, art, and opera.
Theme Song: "The History of Everything" by Barenaked Ladies